Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
نویسندگان
چکیده
منابع مشابه
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.
Coupled cellular respiration requires that ATP and ADP be efficiently exchanged between the cytosol and the mitochondrial matrix. When growth factors are withdrawn from dependent cells, metabolism is disrupted by a defect in ATP/ADP exchange across the mitochondrial membranes. Unexpectedly, we find that this defect results from loss of outer mitochondrial membrane permeability to metabolic anio...
متن کاملPhosphorothioate oligonucleotides reduce mitochondrial outer membrane permeability to ADP.
G3139, an antisense Bcl-2 phosphorothioate oligodeoxyribonucleotide, induces apoptosis in melanoma and other cancer cells. This apoptosis happens before and in the absence of the downregulation of Bcl-2 and thus seems to be Bcl-2-independent. Binding of G3139 to mitochondria and its ability to close voltage-dependent anion-selective channel (VDAC) have led to the hypothesis that G3139 acts, in ...
متن کاملAlteration in the control of mitochondrial respiration by outer mitochondrial membrane and creatine during heart preservation.
OBJECTIVE This study aimed to evaluate the nature and extent of mitochondrial alterations during heart preservation. METHODS Rat hearts, isolated after cardioplegia in situ, were preserved for 6 or 15 h at 4 degrees C either by immersion in cardioplegic solution or by low-flow perfusion (0.3 ml/min) with cardioplegic solution. The energy state of hearts at the end of preservation was determin...
متن کاملAlterations in outer membrane permeability.
INTRODucnON ... ......... ........... .. . .. ........ ... ........ . .. .. ... .. ... . ......... .. ........ . 238 Structure oj the Cell Envelope.................................................................. 238 Uptake Arross the Outer Membrane.......................................................... 239 Intrinsic,Dejects in Outer Membrane Permeability in So.me Bacteria . .... ..... .. ....
متن کاملLevels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology.
Mitochondria undergo balanced fission and fusion events that enable their appropriate networking within the cell. In yeast, three factors have been identified that co-ordinate fission events at the mitochondrial outer membrane. Fis1p acts as the outer membrane receptor for recruitment of the dynamin member, Dnm1p and the WD40-repeat-containing protein Mdv1p. In mammals, the Dnm1p counterpart Dr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.090082297